Thyretain® TBI Blocking Reporter BioAssay
Thyretain® BioAssays
Thyretain® TBI Blocking Reporter BioAssay

NOT AVAILABLE FOR SALE IN THE U.S.

Thyroid Blocking Immunoglobulin (TBI) are antibodies against The thyrotropin receptor (TSHR) that prevent thyrotropin (TSH) binding to the receptor causing an inhibition of TSH action and can induce hypothyroidism.

TSHR is a primary autoantigen in autoimmune thyroid disease (AITD). Autoantibodies (Ab) against the TSHR can be present either as functional thyroid-stimulating autoantibodies (TSI) causing Graves’ hyperthyroidism or as thyroid-blocking autoantibodies (TBI) causing hypothyroidism.

Measurement of these Thyroid Receptor Blocking autoantibodies can prove useful in the following areas:

  • Differential diagnosis of thyroiditis (unexplained Goiter)
  • Autoimmune Hashimoto‘s Thyroiditis (HT)
  • Graves‘ disease: post radioactive iodine treatment and/or during therapy with antithyroid drugs (some patients having both stimulating and blocking antibodies simultaneously)
  • Differential diagnosis of hypothyroidism; AITD
  • Postpartum thyroid disease, possibly PP depression
  • Autoimmune thyroid disease developing during pregnancy
  • Pediatric monitoring
  • Additional yet unknown applications

Knowing if it's thyroid-stimulating immunoglobulin (TSI) or thyroid-blocking immunoglobulin (TBI) matters. For information about Graves' disease and the Thyretain TSI Blocking Reporter BioAssay, learn more.

Please see chart below for ordering information. 

Contact us

Thyretain® BioAssays
Thyretain® TBI Blocking Reporter BioAssay
Thyretain® TBI Blocking Reporter BioAssay

NOT AVAILABLE FOR SALE IN THE U.S.

Thyroid Blocking Immunoglobulin (TBI) are antibodies against The thyrotropin receptor (TSHR) that prevent thyrotropin (TSH) binding to the receptor causing an inhibition of TSH action and can induce hypothyroidism.

TSHR is a primary autoantigen in autoimmune thyroid disease (AITD). Autoantibodies (Ab) against the TSHR can be present either as functional thyroid-stimulating autoantibodies (TSI) causing Graves’ hyperthyroidism or as thyroid-blocking autoantibodies (TBI) causing hypothyroidism.

Measurement of these Thyroid Receptor Blocking autoantibodies can prove useful in the following areas:

  • Differential diagnosis of thyroiditis (unexplained Goiter)
  • Autoimmune Hashimoto‘s Thyroiditis (HT)
  • Graves‘ disease: post radioactive iodine treatment and/or during therapy with antithyroid drugs (some patients having both stimulating and blocking antibodies simultaneously)
  • Differential diagnosis of hypothyroidism; AITD
  • Postpartum thyroid disease, possibly PP depression
  • Autoimmune thyroid disease developing during pregnancy
  • Pediatric monitoring
  • Additional yet unknown applications

Knowing if it's thyroid-stimulating immunoglobulin (TSI) or thyroid-blocking immunoglobulin (TBI) matters. For information about Graves' disease and the Thyretain TSI Blocking Reporter BioAssay, learn more.

Please see chart below for ordering information. 

Contact us

Ordering information
Catalog number Description Kit size / Case size
40-35010 Thyretain TBI Blocking Reporter BioAssay 
 Includes:
  Thyretain FreshFrozenCells and Control Set 1
  Thyretain Media Set 1
  Luciferase Assay Reagent Sets 10

 


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Technical documentation

Product specifications
CHO Mc4 FreshFrozenCells Store at –70°C or lower  
Control set (positive, negative, reference) Store at –70°C or lower  
Cell attachment solution* Store at 2°C to 30°C
Growth medium Store at 2°C to 30°C
Reaction buffer Store at 2°C to 30°C
Luciferase assay reagent set Store at –20°C or lower