Factor B (Bb) Protein
Purified human Factor Bb protein
Product Specifications
| Citations | 0 |
|---|---|
| Description |
Purified human Factor Bb protein |
| Storage | Store at -70°C or below. Avoid freeze/thaw. |
| Form |
Frozen liquid. Phosphate-buffered saline, pH 7.3. No preservative, 0.22 µm filtered. |
| Concentration | 1.0 mg/mL (refer to CoA for lot specific concentration) |
| Applications |
See citations and technical data sheet for application info. |
Ordering Information
| Catalog Number | A416 |
|---|---|
| Catalog Number (CE) | N/A |
| Size | 250 µL |
| Price (USD) | $600.00 |
| Price (EURO) | 510,00 € |
Contact us
| US Phone | +1 (858) 552 1100 |
|---|---|
| EU Phone | +353 (91) 412 474 |
| US Email | contact-us@quidelortho.com |
| EU Email | contact-emea@quidelortho.com |
- Specifications
- Citations
- Certificate of Analysis
Specifications
| Description |
Purified human Factor Bb protein |
|---|---|
| Size | 250 µL |
| Storage |
Store at -70°C or below. Avoid freeze/thaw. |
| Form | Frozen liquid. Phosphate-buffered saline, pH 7.3. No preservative, 0.22 µm filtered. |
| Concentration | 1.0 mg/mL (refer to CoA for lot specific concentration) |
| Applications | See citations and technical data sheet for application info. |
| Purity | >95% by SDS-PAGE |
| Source |
Normal human serum |
| Activity | No activity |
| Molecular Weight | 60,000 Da (single chain) |
| Background |
Centrally important to the alternative pathway is the zymogen Factor B. Factor B is a 93 kD protein which is converted to an active proteolytic enzyme via a two step reaction involving C3b and Factor D. Factor B binds to C3b (or hydrolyzed C3) either in fluid phase or on a membrane or other surface. In the second step, Factor D cleaves the bound Factor B to yield Ba (33 kD) and Bb (60KD) The resulting bimolecular complex is the alternative pathway convertase and is capable of cleaving additional C3 or, together with a second C3b molecule, C5. |
Citations
| Title | Year | Applications | Sample Species | Sample | Sample Details |
|---|
Certificate of Analysis
