Factor H Protein

Purified human Factor H protein


Product Specifications

Citations 10
Description

Purified human Factor H protein

Storage Store at -70°C or below. Avoid freeze/thaw.
Form

Frozen liquid. 10 mM Sodium phosphate, 145 mM NaCl, pH 7.2. No preservative, 0.22 µm filtered.

Concentration 1.0 mg/mL (refer to CoA for lot specific concentration)
Applications

See citations and technical data sheet for application info.

Ordering Information

For Research Use Only. Not for use in diagnostic procedures.
Catalog Number A410
Catalog Number (CE) N/A
Size 250 µL
Price (USD) $315.00
Price (EURO) 280,00 €

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Specifications

Description

Purified human Factor H protein

Size 250 µL
Storage

Store at -70°C or below. Avoid freeze/thaw.

Form Frozen liquid. 10 mM Sodium phosphate, 145 mM NaCl, pH 7.2. No preservative, 0.22 µm filtered.
Concentration 1.0 mg/mL (refer to CoA for lot specific concentration)
Applications See citations and technical data sheet for application info.
Purity >90% by SDS-PAGE
Source

Normal human serum

Activity >90% versus normal human serum standard
Molecular Weight 155,000 Da (single chain)
Background

Purified human complement Factor H. Factor H is a fluid phase complement regulatory protein. It consists of a single peptide chain with a molecular weight of 155 kD. Factor H regulates the formation of the alternative pathway convertase enzyme by functioning as a cofactor for cleavage of C3b by Factor I.

Citations

Title Year Applications Sample Species Sample Sample Details

Recurrent infections in partial complement factor I deficiency: evaluation of three generations of a Brazilian family

2006

ELISA

Human

Plasma

Interaction of pneumococcal histidine triad proteins with human complement

2010

ELISA, FC

Bacteria

Streptococcus pneumoniae

Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases

2011

ELISA

Human

Serum

Reduction of complement factor H binding to CLL cells improves the induction of rituximab-mediated complement-dependent cytotoxicity

2013

WB

Cell Culture

CLL Cells

Antigenic Variation in Streptococcus pneumoniae PspC Promotes Immune Escape in the Presence of Variant-Specific Immunity

2018

WB

N/A

Purified protein

PspC

Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking

2021

ELISA

Human

Plasma

Local complement factor H protects kidney endothelial cell structure and function

2021

IF

Human, Mouse

Kidney Tissue

Plasmodium falciparum Gametes and Sporozoites Hijack Plasmin and Factor H To Evade Host Complement Killing

2023

WB

Parasite

Cell Culture

Plasmodium falciparum

Humoral complementomics - exploration of noninvasive complement biomarkers as predictors of renal cancer progression

2024

Multiplex

Human

Plasma

Renal Cancer

The Sialome of the Retina, Alteration in Age-Related Macular Degeneration Pathology, and Potential Impacts on Complement Factor H

2025

IHC

Human

Eye Tissue

Age-Related Macular Degeneration

Intracellular complement Factor H promotes tumor progression through modulation of cell cycle and actin cytoskeleton

2026

ELISA

Purified Protein

Purified Protein

Cancer