C1q Protein

Purified human C1q protein

Product Specifications

Citations	31
Description	Purified human C1q protein
Storage	Store at -70°C or below. Avoid freeze/thaw.
Form	Frozen liquid. 10 mM HEPES, 300 mM NaCl, pH 7.2, 40% glycerol, no preservative, 0.22 µm filtered.
Concentration	1.0 mg/mL (refer to CoA for lot specific concentration)
Applications	See citations and technical data sheet for application info.

Technical Documents

Ordering Information

For Research Use Only. Not for use in diagnostic procedures.

Catalog Number	A400
Catalog Number (CE)	N/A
Size	1.0 ml
Price (USD)	$325.00
Price (EURO)	290,00 €

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US Phone	+1 (858) 552 1100
EU Phone	+353 (91) 412 474
US Email	customerservice@quidelortho.com
EU Email	EMEACustomerService@quidelortho.com

Specifications
Citations
Certificate of Analysis

Specifications

Description	Purified human C1q protein
Size	1.0 ml
Storage	Store at -70°C or below. Avoid freeze/thaw.
Form	Frozen liquid. 10 mM HEPES, 300 mM NaCl, pH 7.2, 40% glycerol, no preservative, 0.22 µm filtered.
Concentration	1.0 mg/mL (refer to CoA for lot specific concentration)
Applications	See citations and technical data sheet for application info.
Purity	≥95% by SDS PAGE
Source	Normal human serum
Activity	> 1,000,000 C1H50 units/mg
Molecular Weight	410,000 Da (18 chains)
Background	Purified human complement component C1q. Circulating C1q protein is a hexamer of three unique protein subunits (A, B, and C) with molecular weights of 29, 26 and 22 kD respectively. The assembled hexamer contains a central core or stalk, 6 collagen-like domains and 6 globular protein heads. These globular or terminal regions are responsible for the binding of immunoglobulins (IgM and IgG). As part of the C1 complex (together with two copies each of C1r and C1s) C1q is central to activation of the classical complement pathway.

Citations

Title	Year	Applications	Sample Species	Sample	Sample Details
Presence of plasma complement regulatory proteins clusterin (Apo J) and vitronectin (S40) on circulating immune complexes (CIC)	2006	ELISA	N/A	Purified protein	Standard curve generation
Highly specific inhibition of C1q globular-head binding to human IgG: a novel approach to control and regulate the classical complement pathway using an engineered single chain antibody variable fragment	2008	ELISA	Hamster	CHO Cells	pEE-QuVHVL Transfected
Structural characterization of a human Fc fragment engineered for lack of effector functions	2008	ELISA	N/A	C1q Protein
Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium	2008	WB	Human	Purified protein
Local inflammation induces complement crosstalk which amplifies the antimicrobial response	2009	ELISA	N/A	C1q Protein
Alternative complement pathway deregulation is correlated with dengue severity	2009	ELISA	Human	Plasma	Dengue
Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells	2009	IF	Human	Prostate Tissue
Complement C1q enhances homing-related responses of hematopoietic stem/progenitor cells	2010	Chemotaxis Assay	Human	Hematopoietic stem/progenitor cells
Mutations within a human IgG2 antibody form distinct and homogeneous disulfide isomers but do not affect Fc gamma receptor or C1q binding	2010	ELISA	N/A	CD44 (coating)
Expression of complement components, receptors and regulators by human dendritic cells	2011	ELISA	Human	Dendritic Cell
Tim-3 negatively regulates IL-12 expression by monocytes in HCV infection	2011	FC	Human	Peripheral blood mononuclear cells
Natural antibody to apoptotic cell membranes inhibits the proinflammatory properties of lupus autoantibody immune complexes	2012	Complement Activation Assay	Cell Culture	C57BL/6	Bone marrow cells
MBL interferes with endovascular trophoblast invasion in pre-eclampsia	2012	ELISA	Human	Extravillous trophoblast cells
Quantitative evaluation of fucose reducing effects in a humanized antibody on Fcγ receptor binding and antibody-dependent cell-mediated cytotoxicity activities	2012	ELISA	N/A	CD-20 Antibody (AbX)
The salivary scavenger and agglutinin binds MBL and regulates the lectin pathway of complement in solution and on surfaces	2012	ELISA	N/A	rSALSA
C6 knock-out mice are protected from thrombophilia mediated by antiphospholipid antibodies	2012	ELISA	Human	IgG Antibody	IgG-APS, IgG-MHS, IgM-APS, IgM-NHS
The natural human IgM antibody PAT-SM6 induces apoptosis in primary human multiple myeloma cells by targeting heat shock protein GRP78	2013	ELISA	N/A	PAT-SM6 Antibody (coating)
SIGN-R1, a C-type lectin, enhances apoptotic cell clearance through the complement deposition pathway by interacting with C1q in the spleen	2013	FC	Human	Thymocyte Cells
Intramolecular immunological signal hypothesis revived--structural background of signalling revealed by using Congo Red as a specific tool	2015	Complement Activation Assay	Sheep	Red Blood Cells
Complement protein C1q modulates neurite outgrowth in vitro and spinal cord axon regeneration in vivo	2015	ELISA, IP	Mouse	Brain Tissue	Cerebellum myelin substrate
Non-Complement-Binding De Novo Donor-Specific Anti-HLA Antibodies and Kidney Allograft Survival	2016	Binding Assay	Human	Serum	dnDSA
Apoptosis signal-regulating kinase 1 mediates striatal degeneration via the regulation of C1q	2016	Complement Activation Assay	Rat	Protein Injection
Evading pre-existing anti-hinge antibody binding by hinge engineering	2016	ELISA	Human	Serum	Anti-hinge antibodies
C1q Deficiency and Neuropsychiatric Systemic Lupus Erythematosus	2016	ELISA	Human	Serum
Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice	2017	ELISA	Human	C1q Protein	Binding Assay
Complement C1q stimulates the progression of hepatocellular tumor through the activation of discoidin domain receptor 1	2018	Cell Migration Assay	Cell Culture	HepG2 cells
rIgG1 Fc Hexamer Inhibits Antibody-Mediated Autoimmune Disease via Effects on Complement and FcγRs	2018	ELISA	Human	Serum	Fc activation
The Surface-Exposed Protein SntA Contributes to Complement Evasion in Zoonotic Streptococcus suis	2018	ELISA	Human	Purified protein
Number of individual ACPA reactivities in synovial fluid immune complexes, but not serum anti-CCP2 levels, associate with inflammation and joint destruction in rheumatoid arthritis	2018	ELISA	Human	Serum	Immune Complexes
EGFR modulates complement activation in head and neck squamous cell carcinoma	2020	IF	Cell Culture	HNSCC Cells
Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking	2021	Protein Assay	Human	Plasma
Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain	2024	Liquid-liquid phase separation assay	Human	Purified protein
C1q Binds to CD4+ T Cells and Inhibits the Release of Pro-Inflammatory Cytokines: Role in the Pathogenesis of Systemic Lupus Erythematosus	2025	Complement Activation Assay	Cell Culture	Molt-4 Cells	Systemic lupus erythematosus
Thrombin Generation Induced by Complement Component C1q Interaction With the Receptor for the Globular Head of C1q on Adventitial Fibroblasts and Vascular Smooth Muscle Cells	2026	Complement Activation Assay	Human	Smooth Muscle Cells
Thrombin Generation Induced by Complement Component C1q Interaction With the Receptor for the Globular Head of C1q on Adventitial Fibroblasts and Vascular Smooth Muscle Cells	2026	Complement Activation Assay	Human	Aortic adventitial fibroblasts

Certificate of Analysis

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