According to the World Health Organization, there are 9.4 million deaths per year due to ischemic (reduced blood-flow-related) heart disease.1 In the U.S. alone, 750,000 patients suffer from a heart attack every year.2 A heart attack is an urgent, time-critical emergency that requires the fastest intervention to preserve the best patient outcomes possible. Chest pain is the second most frequent cause of emergency room visits among adults, amounting to more than 8 million visits annually nationwide, but a UC San Francisco study found that only 5.5 percent of those visits led to serious diagnoses, such as heart attacks.3
High-Sensitivity Troponin I Assay features and benefits
Fully compliant with the IFCC definition4 for high-sensitivity troponin assays
Exceptional analytical sensitivity and precision, enabling early MI detection using serial measurements and the 99th percentile upper reference limits
High negative predictive value for confident early rule-out decisions
Minimal interference — unaffected by biotin and resistant to common assay interferences
- Specifications
| Highly competitive analytical/operational performance | |
| Time to first result | 15 mins |
| On analyzer stability | Up to 4 weeks when system remains powered on |
| Negative Predictive Value (NPV) | All Subjects using 11 ng/L Cutoff 0–2 hours: 98.57% ≥2–4 hours: 98.90% |
| Sample type | Plasma (lithium heparin) |
| Sample volume | 60 μL |
| Calibration interval | 28 days |
1WHO Disease burden and mortality estimates, 2016. Accessed August 11, 2022. https://www.who.int/data/global-health-estimates
2Mozzafarian D, Benjamin EJ, Go AS, et al. Heart disease and stroke statistics—2016 update: A report from the American Heart Association [published correction appears in Circulation. 2016;133(15):e599]. Circulation. 2016;133:e38- e360. doi:10.1161/CIR.0000000000000350
3Hsia RY, Hale Z, Tabas JA. A national study of the prevalence of life-threatening diagnoses in patients with chest pain. JAMA Intern Med. 2016;176(7):1029-1032. doi:10.1001/jamainternmed.2016.2498
4 Wu AHB, Christenson RH, Greene DN, et al. Clinical Laboratory Practice Recommendations for the Use of Cardiac Troponin in Acute Coronary Syndrome: Expert Opinion from the Academy of the American Association for Clinical Chemistry and the Task Force on Clinical Applications of Cardiac Bio-Markers of the International Federation of Clinical Chemistry and Laboratory Medicine. Clin Chem. 2018;64(4):645–655. doi:10.1373/clinchem.2017.277186.
