C8 Antibody (Monoclonal)

A murine monoclonal antibody to an epitope on C8 protein.

1.0-1.2 mg/mL

Mouse

Short term (30 days) 4˚C. Long term at or below –20˚C.

Complement component C8 is a plasma glycoprotein with a molecular weight of 150 kD. C8 protein is present in human plasma at a concentration of approximately 70 µg/mL. Complement component C8 is unique to the Terminal Complement pathway. It is composed of three protein chains (α-65 kD, β-65 kD and γ-22 kD). Together with the other proteins of the Terminal pathway, C8 forms the Membrane Attack Complex or MAC. The Terminal Complement Complex (TCC) is the general term for both membrane bound C5b-9 (the MAC) and fluid phase SC5b-9. C5b-9 is formed through activation of the Terminal pathway via either the Classical or Alternative Complement pathways. Assessment of the TCC is an excellent marker for quantifying the extent of Terminal pathway activation in vivo or in vitro. TCC can be deposited on the su rface of transformed cells, biomaterials, and a variety of other surfaces.