C1s Antibody (Polyclonal)

A goat antiserum raised against human C1s protein.


Product Specifications

Citations 8
Clonality

Polyclonal

Immunogen Highly purified human C1s protein
Applications See citations and technical data sheet for application info.
Concentration > 40 mg/mL
Conjugate Unconjugated
Cross Reactivity

Human, Baboon

Ordering Information

For Research Use Only in the United States. Not for use in diagnostic procedures.
Catalog Number A302
Catalog Number (CE) N/A
Size 2.0 mL
Price (USD) $195.00
Price (EURO) 170,00 €

Contact us

US Phone+1 (858) 552 1100
EU Phone+353 (91) 412 474
US Emailcontact-us@quidelortho.com
EU Emailcontact-emea@quidelortho.com

Specifications

Description

A goat antiserum raised against human C1s protein.

Size 2.0 mL
Concentration

> 40 mg/mL

Applications See citations and technical data sheet for application info.
Form Liquid. Whole Antiserum. ≤ 0.1% Sodium Azide
Clonality Polyclonal
Immunogen Highly purified human C1s protein
Conjugate Unconjugated
Cross Reactivity Human, Baboon
Isotype Goat IgG
Purity N/A
Source

Goat

Specificity The Anti-human C1s polyclonal antisera was tested against normal human plasma by double immunodiffusion, one-dimensional immunoelectrophoresis, quantitative radial immunodifussion, and quantitative rocket immunoelectrophoresis. The antiserum was determined to be monospecific for C1s at varying concentrations.
Storage

Short term (30 days) 4˚C. Long term at or below –20˚C.

Background

The C1s molecule is a monomeric zymogen protein with a molecular weight of 86 kD. In normal human serum the accepted concentration of C1s is approximately 34 µg/mL. C1s is one of 3 subcomponents that together make the first component of the classical complement pathway, C1. Initiation of the classical complement pathway occurs when C1q binds with IgM or IgG containing antigen-antibody complexes. Upon activation by C1r, the C1s monomer is fragmented into 2 disulfide-linked polypeptide chains, A and B. The enzymatically active site of the C1s molecule is located in the B fragment. With the proteolysis of C1s, C1 becomes active and can then begin to act upon C4 and C2. C1s cleaves C4 into C4a and C4b. C4b then acts as a receptor for C2. Once bound, the C2 becomes a substrate for C1s, which then cleaves C2 into C2a and C2b. C2b remains bound to the C4b creating the C3/C5 convertase of the classical complement pathway.