Klotho Antibody (KL1)

A mouse monoclonal antibody to human Klotho.


Product Specifications

Citations 0
Clonality

Monoclonal

Immunogen Purified human klotho protein.
Applications See citations and technical data sheet for application info.
Concentration Varies (refer to CoA)
Conjugate Unconjugated
Cross Reactivity

None

Ordering Information

For Research Use Only. Not for use in diagnostic procedures.
Catalog Number 21-9159
Catalog Number (CE) N/A
Size 100 µg
Price (USD) $415.00
Price (EURO) 370,00 €

Contact us

US Phone+1 (858) 552 1100
EU Phone+353 (91) 412 474
US Emailcontact-us@quidelortho.com
EU Emailcontact-emea@quidelortho.com

Specifications

Description

A mouse monoclonal antibody to human Klotho.

Size 100 µg
Concentration

Varies (refer to CoA)

Applications See citations and technical data sheet for application info.
Form Liquid. Phosphate Buffered Solution (PBS), with 0.1% sodium azide
Clonality Monoclonal
Immunogen Purified human klotho protein.
Conjugate Unconjugated
Cross Reactivity None
Isotype IgG1λ
Purity ≥ 95% by SDS PAGE
Source

Mouse

Specificity The specificity of the monoclonal antibody was established via epitope mapping and a series of immunoassays. The antibody binds the KL1 domain of the Klotho protein.
Storage

Short term (30 days) 4˚C. Long term at or below –20˚C.

Background

Klotho is a type-I transmembrane protein that is associated with many functions. A novel ß-glucuronidase, Klotho has been associated with phosphate regulation, organ protection, and aging, among others. Though a single gene, it has three major isoforms: the transmembrane form, a shed soluble form, and a truncated soluble form. The extracellular portion of the protein consists of two glycosyl hydrolase domains referred to as KL1 and KL2. Upon cleavage at the base of the extracellular domain the protein becomes the shed soluble form and is an active form that functions as a hormone. Importantly, Klotho is a receptor and a co-receptor of the phosphate regulation protein FGF-23. While Klotho/FGF-23 homeostasis has primarily been focused on phosphate and vitamin D regulation, continuing research is associating Klotho and FGF-23 with functionality that impacts the heart, bones, blood vessels, and parathyroid gland.

Citations

Title Year Applications Sample Species Sample Sample Details