Factor I Antibody (Monoclonal)

A murine monoclonal antibody to an epitope Factor I.


Product Specifications

Citations 4
Clonality

Monoclonal

Immunogen Purified human protein.
Applications See citations and technical data sheet for application info.
Concentration 1.0-1.2 mg/mL
Conjugate Unconjugated
Cross Reactivity

Human

Ordering Information

For Research Use Only in the United States. Not for use in diagnostic procedures.
Catalog Number A247
Catalog Number (CE) N/A
Size 100 µl
Price (USD) $365.00
Price (EURO) 330,00 €

Contact us

US Phone+1 (858) 552 1100
EU Phone+353 (91) 412 474
US Emailcontact-us@quidelortho.com
EU Emailcontact-emea@quidelortho.com

Specifications

Description

A murine monoclonal antibody to an epitope Factor I.

Size 100 µl
Concentration

1.0-1.2 mg/mL

Applications See citations and technical data sheet for application info.
Form Liquid. Borate Buffered Saline (pH 8.4 ± 0.2), with ≤ 0.1% Sodium Azide.
Clonality Monoclonal
Immunogen Purified human protein.
Conjugate Unconjugated
Cross Reactivity Human
Isotype IgG1k
Purity ≥ 95% by SDS PAGE
Source

Mouse

Specificity This monoclonal antibody was raised against purified human Factor I. This antibody blocks function of Factor I.
Storage

Short term (30 days) 4˚C. Long term at or below –20˚C.

Background

Factor I is one of the complement proteins which is unique to the Alternative Pathway. It is a 88 kD glycoprotein composed of heavy (50 kD) and light (38 kD) chains linked by disulphide bonds. Factor I is a highly specific serine protease which cleaves the alpha chain of C3b and C4b leading to the formation of iC3b and C3f, followed by C3c and C3d,g. It does not function effectively without a cofactor, such as Factor H, CR1, MCP or CR2. The concentration of Factor I in human serum/plasma is ~34 µg/ml. The Alternative Complement Pathway provides innate protection against microbial agents in the absence of specific antibodies. The activation of this complement pathway can be triggered by a variety of substances, including microbial polysaccharaides or lipids, gram-negative bacterial lipopolysaccharides, and surface determinants present on some viruses, parasites, virally infected mammalian cells, and cancer cells. In autoimmune diseases, the Alternative Complement Pathway may contribute directly to tissue damage.