C2 Antibody (Polyclonal)

Purified Ig from goat antiserum raised against human C2 protein.


Product Specifications

Citations 2
Clonality

Polyclonal

Immunogen Highly purified human C2 protein
Applications See citations and technical data sheet for application info.
Concentration > 20 mg/mL
Conjugate Unconjugated
Cross Reactivity

Human

Ordering Information

For Research Use Only in the United States. Not for use in diagnostic procedures.
Catalog Number A303
Catalog Number (CE) N/A
Size 1.0 mL
Price (USD) $250.00
Price (EURO) 205,00 €

Contact us

US Phone+1 (858) 552 1100
EU Phone+353 (91) 412 474
US Emailcontact-us@quidelortho.com
EU Emailcontact-emea@quidelortho.com

Specifications

Description

Purified Ig from goat antiserum raised against human C2 protein.

Size 1.0 mL
Concentration

> 20 mg/mL

Applications See citations and technical data sheet for application info.
Form Liquid. Phosphate-buffered saline, pH 7.2. ≤ 0.1% Sodium Azide
Clonality Polyclonal
Immunogen Highly purified human C2 protein
Conjugate Unconjugated
Cross Reactivity Human
Isotype Goat IgG
Purity IgG Purified
Source

Goat

Specificity The anti-human C2s polyclonal antisera was tested against normal human serum by double immunodiffusion, quantitative radial immunodiffusion, and ELISA. The antiserum was determined to be monospecific for C2 at varying concentrations.
Storage

Short term (30 days) 4˚C. Long term at or below –20˚C.

Background

C2 is a polypeptide, which is present in normal human serum/plasma at approximately 20 µg/mL. This complement protein is synthesized in a variety of locations throughout the body with the main site of synthesis being the liver. It has an approximate molecular weight of 100 kD, however, the molecular weight can vary due to the natural glycosylation of the protein at 8 different sites. C2 is a key component in both the classical and lectin pathways of complement activation, as the fragments are utilized to form both the C3 and C5 convertases after C2 is cleaved to produce C2a and C2b. These fragments have molecular weights of approximately 70 kD and kD, respectively. C2a binds to C4b to form the C3 convertase, and then the C2a, C4b complex binds to C3b to form the C5 convertase. Formation of both convertase molecules is essential to the continuation of the complement cascade, with the final results being the formation of the Membrane Attack Complex, or MAC.