Factor P Antibody (Monoclonal - #2)
A murine monoclonal antibody to an epitope on Factor P.
Product Specifications
Citations | 9 |
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Clonality |
Monoclonal |
Immunogen | Purified human protein. |
Applications | See citations and technical data sheet for application info. |
Concentration | 1.0-1.2 mg/mL |
Conjugate | Unconjugated |
Cross Reactivity |
Human |
Ordering Information
Catalog Number | A235 |
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Catalog Number (CE) | N/A |
Size | 100 µl |
Price (USD) | $365.00 |
Price (EURO) | 330,00 € |
Contact us
US Phone | +1 (858) 552 1100 |
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EU Phone | +353 (91) 412 474 |
US Email | contact-us@quidelortho.com |
EU Email | contact-emea@quidelortho.com |
- Specifications
- Citations
- Certificate of Analysis
Specifications
Description |
A murine monoclonal antibody to an epitope on Factor P. |
---|---|
Size | 100 µl |
Concentration |
1.0-1.2 mg/mL |
Applications | See citations and technical data sheet for application info. |
Form | Liquid. Borate Buffered Saline (pH 8.4 ± 0.2), with ≤ 0.1% Sodium Azide. |
Clonality | Monoclonal |
Immunogen | Purified human protein. |
Conjugate | Unconjugated |
Cross Reactivity | Human |
Isotype | IgG1k |
Purity | ≥ 95% by SDS PAGE |
Source |
Mouse |
Specificity | This monoclonal antibody was raised against purified human Factor P. It does not inhibit function of Factor P. |
Storage |
Short term (30 days) 4˚C. Long term at or below –20˚C. |
Background |
The function of Properdin (Factor P) is to stabilize the alternative pathway convertase. Its binding to C3bBb extends the half-life of the complex. The concentration in plasma is approximately 20 μg/mL. Factor P has a molecular weight of 224 kDa, consisting of four identical chains of approximately 53 kDa molecular weight. The alternative complement pathway provides innate protection against microbial agents in the absence of specific antibody. The activation of this complement pathway can be triggered by a variety of substances, including microbial polysaccharides or lipids, gram-negative bacterial lipopolysaccharides, and surface determinants present on some viruses, parasites, virally infected mammalian cells and cancer cells. In autoimmune diseases, the alternative complement pathway may contribute directly to tissue damage. |
Citations
Title | Year | Applications | Sample Species | Sample | Sample Details |
---|---|---|---|---|---|
2019 | ELISA |
Human |
Whole Blood |
Heme, various concentrations |
|
2021 | ELISA |
Human |
Plasma |
||
2021 | ELISA |
Human |
Plasma |
Congenital Thrombocytopenia |
|
2021 | ELISA |
Human |
Plasma |
Heart Failure |
|
2016 | ELISA |
Human |
Synovial fluid |
||
2014 | ELISA, Complement Activation Assay |
Human |
Plasma |
||
Properdin binding to complement activating surfaces depends on initial C3b deposition |
2017 | ELISA, WB |
Human |
Serum |
|
2011 | IF, FC |
Human |
Serum |
||
2024 | ELISA |
Human |
Plasma |
COVID-19 |