Factor B Antibody (Polyclonal)
A goat antiserum raised against human Factor B.
Product Specifications
Citations | 18 |
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Clonality |
Polyclonal |
Immunogen | Highly purified human Factor B protein |
Applications | See citations and technical data sheet for application info. |
Concentration | > 40 mg/mL |
Conjugate | Unconjugated |
Cross Reactivity |
Human, Baboon, Horse, Dog, Cat, Rabbit, Hamster, Mouse, Rat, Guinea Pig, Swine |
Ordering Information
Catalog Number | A311 |
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Catalog Number (CE) | N/A |
Size | 2.0 mL |
Price (USD) | $195.00 |
Price (EURO) | 170,00 € |
Contact us
US Phone | +1 (858) 552 1100 |
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EU Phone | +353 (91) 412 474 |
US Email | contact-us@quidelortho.com |
EU Email | contact-emea@quidelortho.com |
- Specifications
- Citations
- Certificate of Analysis
Specifications
Description |
A goat antiserum raised against human Factor B. |
---|---|
Size | 2.0 mL |
Concentration |
> 40 mg/mL |
Applications | See citations and technical data sheet for application info. |
Form | Liquid. Whole Antiserum. ≤ 0.1% Sodium Azide |
Clonality | Polyclonal |
Immunogen | Highly purified human Factor B protein |
Conjugate | Unconjugated |
Cross Reactivity | Human, Baboon, Horse, Dog, Cat, Rabbit, Hamster, Mouse, Rat, Guinea Pig, Swine |
Isotype | Goat IgG |
Purity | N/A |
Source |
Goat |
Specificity | The Anti-Human Factor B polyclonal antisera was tested by double-immunodiffusion, one-dimensional immunoelectrophoresis, quantitative radial immunodiffusion, and quantitative rocket immunoelectrophoresis. The antisera was determined to be monospecific for the Factor B protein. |
Storage |
Short term (30 days) 4˚C. Long term at or below –20˚C. |
Background |
Primarily synthesized in the liver, Factor B is a plasma protein that is unique to the alternative pathway of the Complement system. The average concentration of Factor B in human serum/plasma is approximately 200 µg/mL. Factor B present in the circulatory system is a single-chain polypeptide with a molecular weight of 93 KD. Factor B will bind to the C3b component of the complement system in the presence of Mg++ to form the C3bB complex. This complex can be activated through cleavage of the Factor B portion by Factor D, which releases the Ba fragment of Factor B while the Bb fragment of Factor B remains bound to C3b. The C3bBb complex acts as a C3 and C5 convertase due to the serine protease activity of the Bb fragment. Presence of the split products (Ba and Bb fragments of Factor B) indicate that the alternative complement pathway has been activated. Factor B, like C2 and C4 is characterized as a Class III major histocompatibility complex (MHC) antigen. The structural gene coding for this protein is located within the MHC on chromosome 6 in man, and chromosome 17 in mice. |
Citations
Title | Year | Applications | Sample Species | Sample | Sample Details |
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2016 | WB |
Bacteria |
Filifactor alocis |
||
2022 | WB |
Bacteria |
A. baumannii |
||
Complement activation in pediatric patients with recurrent acute otitis media |
2013 | IF, WB |
Cell Culture |
HMEE Cells |
|
2022 | ELISA |
Human |
Serum |
||
2015 | ELISA |
Human |
Serum |
N. gonorrhoeae incubated |
|
Variability and action mechanism of a family of anticomplement proteins in Ixodes ricinus |
2008 | ELISA, WB |
Human |
Red Blood Cells |
Ixodes ricinus incubated |
2016 | WB |
Human |
ARPE-19 cells |
||
2021 | WB |
Human |
Retina Tissue |
||
Expression of complement components, receptors and regulators by human dendritic cells |
2011 | WB |
Human |
Monocyte Derived Dendritic Cell |
|
2011 | IF, WB |
Mouse |
Bone Tissue |
Temporal Bone |
|
2011 | IF, WB |
Mouse |
Middle Ear Fluid |
||
Cytokine and Complement Response in the Glaucomatous βB1-CTGF Mouse Model. |
2021 | IHC |
Mouse |
Eye Tissue |
|
C3(H2O) prevents rescue of complement-mediated C3 glomerulopathy in Cfh-/- Cfd-/- mice |
2020 | WB |
Mouse |
Plasma |
|
2021 | WB |
Mouse |
Eye Tissue |
Retina, Sodium Iodate-Induced Degeneration |
|
2022 | WB |
Mouse |
Eye Tissue |
||
2014 | WB |
Mouse |
Plasma |
||
Regulation of C3 Activation by the Alternative Complement Pathway in the Mouse Retina |
2016 | WB |
Mouse |
Plasma |
|
Efficacy of GalNAc C3 siRNAs in factor H-deficient mice with C3 glomerulopathy |
2024 | WB |
Mouse |
Plasma |
C3G |